- MOA: Inhibits NPC1L1 protein. Reduces intestinal cholesterol absorption
- Dose/Admin: 10 mg PO daily with or without food. (5 mg works too)
- Mean LDL-C Reduction: ~20%
- CV Outcomes
- IMPROVE IT: I CV events with mod intensity statin in 2’ prevention
- Generally safe and well tolerated
- Pearls/info
- Generic available - Cheap
- Practical add-on agent
- Dr O’Keefe loves ezetimibe
- EWTOPIA75 study out of Japan: zetia monotherapy vs control
- IMPROVE-IT trial
- compared to folks on simva vs simva +zetia: combo further reduced cardiovascular events