Anti-Hypertensive Medications

First-line therapies

• AHA/ACC 2017: thiazide diuretics, CCBs, and ARBs (IA recommendation)
  • Recommend dual therapy with fixed-dose combo if Stage 2 HTN (i.e., SBP ≥ 140 or DBP ≥ 90) and an average BP > 20/10 mmHg above BP target (IA)
  • 
• ESC/ESH 2018
  • 

Second-line therapies

Combination Drugs

Table source: ¹

Resistant Hypertension

Table source: ¹

Footnotes

1. Azizi M, Vongpatanasin W, Fisher NDL, Mahfoud F, Amar L, Kirtane AJ. Diagnosis and Management of Resistant Hypertension: A Review. JAMA. 2026 Apr 28;335(16):1428-1439. doi: 10.1001/jama.2026.1221. PMID: 41870448. ↩ ↩²