First-line therapies

  • AHA/ACC 2017: thiazide diuretics, CCBs, and ARBs (IA recommendation)
    • Recommend dual therapy with fixed-dose combo if Stage 2 HTN (i.e., SBP ≥ 140 or DBP ≥ 90) and an average BP > 20/10 mmHg above BP target (IA)
  • ESC/ESH 2018

Second-line therapies